NOTE THAT IN THE ALIGNMENTS BELOW, GAPS MOST LIKELY INDICATE
RESIDUES MISSING IN THE ELECTRON DENSITY. 


Alignment: 4GXU_M against 4GXV_H

Length=231
Length=231

 Score =   473 bits (1218),  Expect = 2e-175, Method: Compositional matrix adjust.
 Identities = 231/231 (100%), Positives = 231/231 (100%), Gaps = 0/231 (0%)

Query  1    EVQLVQSGGGVVQPRRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGRNKYY  60
            EVQLVQSGGGVVQPRRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGRNKYY
Sbjct  1    EVQLVQSGGGVVQPRRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGRNKYY  60

Query  61   ADSVKGRFTVSRDNSKNTLYLQMNSLRAEDTSVYYCARELLMDYYDHIGYSPGPTWGQGT  120
            ADSVKGRFTVSRDNSKNTLYLQMNSLRAEDTSVYYCARELLMDYYDHIGYSPGPTWGQGT
Sbjct  61   ADSVKGRFTVSRDNSKNTLYLQMNSLRAEDTSVYYCARELLMDYYDHIGYSPGPTWGQGT  120

Query  121  LVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFP  180
            LVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFP
Sbjct  121  LVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFP  180

Query  181  AVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK  231
            AVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK
Sbjct  181  AVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK  231


Alignment: 4GXU_N against 4GXV_L

Length=217
Length=217

 Score =   437 bits (1125),  Expect = 7e-162, Method: Compositional matrix adjust.
 Identities = 217/217 (100%), Positives = 217/217 (100%), Gaps = 0/217 (0%)

Query  1    EPVLTQPPSASGSPGQRVTISCSGSSSNIGSYTVNWYQQLPGTAPKLLIYSLNQRPSGVP  60
            EPVLTQPPSASGSPGQRVTISCSGSSSNIGSYTVNWYQQLPGTAPKLLIYSLNQRPSGVP
Sbjct  1    EPVLTQPPSASGSPGQRVTISCSGSSSNIGSYTVNWYQQLPGTAPKLLIYSLNQRPSGVP  60

Query  61   DRFSGSKSGTSASLAISGLQSEDEAVYYCAAWDDSLSAHVVFGGGTKLTVLGQPKAAPSV  120
            DRFSGSKSGTSASLAISGLQSEDEAVYYCAAWDDSLSAHVVFGGGTKLTVLGQPKAAPSV
Sbjct  61   DRFSGSKSGTSASLAISGLQSEDEAVYYCAAWDDSLSAHVVFGGGTKLTVLGQPKAAPSV  120

Query  121  TLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAAS  180
            TLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAAS
Sbjct  121  TLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAAS  180

Query  181  SYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS  217
            SYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
Sbjct  181  SYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS  217


Alignment: 4GXU_A against 1RUZ_H

Length=331
Length=328

 Score =   673 bits (1737),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 323/327 (99%), Positives = 324/327 (99%), Gaps = 0/327 (0%)

Query  1    ADPGDTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCN  60
            A   DTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCN
Sbjct  1    ATNADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCN  60

Query  61   IAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEI  120
            IAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEI
Sbjct  61   IAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEI  120

Query  121  FPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVL  180
            FPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVL
Sbjct  121  FPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVL  180

Query  181  WGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEP  240
            WGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEP
Sbjct  181  WGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEP  240

Query  241  GDTITFEATGNLIAPWYAFALNRGSGSGIITSDAPVHDCNTKCQTPHGAINSSLPFQNIH  300
            GDTITFEATGNLIAPWYAFALNRGSGSGIITSDAPVHDCNTKCQTPHGAINSSLPFQNIH
Sbjct  241  GDTITFEATGNLIAPWYAFALNRGSGSGIITSDAPVHDCNTKCQTPHGAINSSLPFQNIH  300

Query  301  PVTIGECPKYVRSTKLRMATGLRNIPS  327
            PVTIGECPKYVRSTKLRMATGLRNIP+
Sbjct  301  PVTIGECPKYVRSTKLRMATGLRNIPA  327


Alignment: 4GXU_B against 1RUZ_I

Length=176
Length=160

 Score =   333 bits (855),  Expect = 2e-122, Method: Compositional matrix adjust.
 Identities = 160/160 (100%), Positives = 160/160 (100%), Gaps = 0/160 (0%)

Query  1    GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMN  60
            GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMN
Sbjct  1    GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMN  60

Query  61   TQFTAVGKEFNNLERRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVRNLYE  120
            TQFTAVGKEFNNLERRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVRNLYE
Sbjct  61   TQFTAVGKEFNNLERRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVRNLYE  120

Query  121  KVKSQLKNNAKEIGNGCFEFYHKCDDACMESVRNGTYDYP  160
            KVKSQLKNNAKEIGNGCFEFYHKCDDACMESVRNGTYDYP
Sbjct  121  KVKSQLKNNAKEIGNGCFEFYHKCDDACMESVRNGTYDYP  160


Alignment: 4GXU_E against 1RUZ_J

Length=331
Length=328

 Score =   673 bits (1737),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 323/327 (99%), Positives = 324/327 (99%), Gaps = 0/327 (0%)

Query  1    ADPGDTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCN  60
            A   DTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCN
Sbjct  1    ATNADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCN  60

Query  61   IAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEI  120
            IAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEI
Sbjct  61   IAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEI  120

Query  121  FPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVL  180
            FPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVL
Sbjct  121  FPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVL  180

Query  181  WGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEP  240
            WGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEP
Sbjct  181  WGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEP  240

Query  241  GDTITFEATGNLIAPWYAFALNRGSGSGIITSDAPVHDCNTKCQTPHGAINSSLPFQNIH  300
            GDTITFEATGNLIAPWYAFALNRGSGSGIITSDAPVHDCNTKCQTPHGAINSSLPFQNIH
Sbjct  241  GDTITFEATGNLIAPWYAFALNRGSGSGIITSDAPVHDCNTKCQTPHGAINSSLPFQNIH  300

Query  301  PVTIGECPKYVRSTKLRMATGLRNIPS  327
            PVTIGECPKYVRSTKLRMATGLRNIP+
Sbjct  301  PVTIGECPKYVRSTKLRMATGLRNIPA  327


Alignment: 4GXU_F against 1RUZ_K

Length=176
Length=160

 Score =   333 bits (855),  Expect = 2e-122, Method: Compositional matrix adjust.
 Identities = 160/160 (100%), Positives = 160/160 (100%), Gaps = 0/160 (0%)

Query  1    GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMN  60
            GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMN
Sbjct  1    GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMN  60

Query  61   TQFTAVGKEFNNLERRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVRNLYE  120
            TQFTAVGKEFNNLERRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVRNLYE
Sbjct  61   TQFTAVGKEFNNLERRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVRNLYE  120

Query  121  KVKSQLKNNAKEIGNGCFEFYHKCDDACMESVRNGTYDYP  160
            KVKSQLKNNAKEIGNGCFEFYHKCDDACMESVRNGTYDYP
Sbjct  121  KVKSQLKNNAKEIGNGCFEFYHKCDDACMESVRNGTYDYP  160


Alignment: 4GXU_C against 1RUZ_L

Length=331
Length=328

 Score =   673 bits (1737),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 323/327 (99%), Positives = 324/327 (99%), Gaps = 0/327 (0%)

Query  1    ADPGDTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCN  60
            A   DTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCN
Sbjct  1    ATNADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCN  60

Query  61   IAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEI  120
            IAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEI
Sbjct  61   IAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEI  120

Query  121  FPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVL  180
            FPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVL
Sbjct  121  FPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVL  180

Query  181  WGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEP  240
            WGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEP
Sbjct  181  WGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEP  240

Query  241  GDTITFEATGNLIAPWYAFALNRGSGSGIITSDAPVHDCNTKCQTPHGAINSSLPFQNIH  300
            GDTITFEATGNLIAPWYAFALNRGSGSGIITSDAPVHDCNTKCQTPHGAINSSLPFQNIH
Sbjct  241  GDTITFEATGNLIAPWYAFALNRGSGSGIITSDAPVHDCNTKCQTPHGAINSSLPFQNIH  300

Query  301  PVTIGECPKYVRSTKLRMATGLRNIPS  327
            PVTIGECPKYVRSTKLRMATGLRNIP+
Sbjct  301  PVTIGECPKYVRSTKLRMATGLRNIPA  327


Alignment: 4GXU_D against 1RUZ_M

Length=176
Length=160

 Score =   333 bits (855),  Expect = 2e-122, Method: Compositional matrix adjust.
 Identities = 160/160 (100%), Positives = 160/160 (100%), Gaps = 0/160 (0%)

Query  1    GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMN  60
            GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMN
Sbjct  1    GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMN  60

Query  61   TQFTAVGKEFNNLERRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVRNLYE  120
            TQFTAVGKEFNNLERRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVRNLYE
Sbjct  61   TQFTAVGKEFNNLERRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVRNLYE  120

Query  121  KVKSQLKNNAKEIGNGCFEFYHKCDDACMESVRNGTYDYP  160
            KVKSQLKNNAKEIGNGCFEFYHKCDDACMESVRNGTYDYP
Sbjct  121  KVKSQLKNNAKEIGNGCFEFYHKCDDACMESVRNGTYDYP  160